Abstract

Background: Visual inspection with acetic acid (VIA) is one of the several methods that can serve as an alternative to the Pap test for diagnosis of precancerous lesions in the cervix. This study aimed to compare the screening value of VIA and Pap test in such diagnosis. Materials and Methods: The population of this descriptive study was 304 women who attended Afzalipour Hospital in Kerman, Iran, from March 2016 to March 2017 that enrolled in the study by the convenience sampling method. Pap test and VIA were performed and followed by colposcopy. Data were analyzed using SPSS software, chi-square and Fisher's exact tests, logistic regression. Results: The result of Pap test in 136 (44.74%), VIA in 200 (65.79%), and colposcopy in 98 (32.24%) patients was positive. The sensitivity and specificity of VIA was 100% and 34.7%, respectively. The sensitivity and specificity of Pap test was 50.0% and 55.3%, respectively. In 93.5% of cervical intraepithelial neoplasia 1 (CIN 1) cases and 100% of CIN 2 and CIN 3 cases, VIA results were true positive (P > 0.999), whereas in 44.2% of CIN 1 cases, 50% of CIN 2 cases, and 42.9% of CIN 3 cases, Pap test results were true positive (P = 0.923). Conclusions: The sensitivity of VIA and Pap test was reflected VIA ability to identify all cases of the disease, but the specificity of VIA was found to be only 34.7%, which means that it will cause additional costs by imposing supplementary tests on healthy individuals (false-positives).