Abstract

Background and objectives: Pistacia vera seed (pistachio) is an edible seed with various therapeutic effects, such as antimicrobial, antioxidant, and antiinflammatory properties. This study aimed to evaluate the oral wound healing effects of Pistacia vera seeds extracts (PSE). Methods: The hydroalcoholic pistachio extract was prepared by the maceration method. A wound was created in the central region of the tongue on the dorsal surface in each rat. The animals were randomly allocated to four groups (n=12). The treated groups orally received 0.5 ml/day of PSE (50, 100, or 200 mg/kg), and the vehicle group orally received 0.5 ml of 10% dimethyl sulfoxide. Each group was divided into three subgroups (n=4), and the animals were sacrificed on days 3, 7, and 10 to acquire the tongue specimens. The number of arteries, as well as the mean percentage of neutrophils, lymphocytes, and fibroblasts, was determined via histopathological examination. Results: The administration of 50 mg/kg of PSE for 10 days showed a beneficial effect on the number of neutrophils and fibroblasts. Conclusion: The present study showed that the hydroalcoholic extract of pistachio could be considered a potential treatment for oral wounds.