Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Vanadium complex: an appropriate candidate for killing hepatocellular carcinoma cancerous cells

(2018) Vanadium complex: an appropriate candidate for killing hepatocellular carcinoma cancerous cells. Biometals. pp. 981-990. ISSN 0966-0844

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Abstract

Hepatocellular carcinoma (HCC) is a prevalent human malignancy which its drug resistance is increasing world-wide. This project was designed to assess the anti-cancer effects of 4-bromo-2-(((5-chloro-2-hydroxyphenyl) imino) methyl) phenol (IV(L) complex) on the HepG2 cell line and also L929 cells, as normal cells. HepG2 and L929 cells were cultured in RPMI culture medium and the survival rates of the cells were determined after 24 and 48h using MTT assay to find IC50 concentration of vanadium m, IV(L) complex. The early apoptosis and necrosis/late apoptosis were determined by means of annexin V/PI apoptosis detection kit. The results revealed that vanadium m, IV(L) complex induce early apoptosis higher in HepG2 cell line than L929 cells. The rates of necrosis/late apoptosis were also induced in HepG2 cells more than L929 cells. Based on the results, vanadium m, IV(L) complex might be considered as a safe new drug for treatment of HCC with low side effects on control liver cells.

Item Type: Article
Keywords: Vanadium complex HepG2 cells L929 cells Hepatocellular carcinoma Cytotoxicity ray crystal-structure schiff-base ligands in-vitro spectral characterization anticancer activity dioxido-vanadium(v) complexes antimicrobial activity drug-resistance hepg2 cells chemotherapy Biochemistry & Molecular Biology
Page Range: pp. 981-990
Journal or Publication Title: Biometals
Journal Index: ISI
Volume: 31
Number: 6
Identification Number: https://doi.org/10.1007/s10534-018-0139-x
ISSN: 0966-0844
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/3003

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