Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

IL-17A and IL-23: plausible risk factors to induce age-associated inflammation in Alzheimer's disease

(2018) IL-17A and IL-23: plausible risk factors to induce age-associated inflammation in Alzheimer's disease. Immunological Investigations. pp. 812-822. ISSN 0882-0139

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Abstract

Background: Aging and its complications such as Alzheimer's disease (AD) are associated with chronic low-grade inflammation entitled age-associated inflammation. However, the main mechanisms whichinduce age-associated inflammation in aging and AD are yet to beclarified. L-23/IL-17A axis plays important roles in the induction of inflammation and consequently autoimmune disease. This review evaluates the main roles played by IL-17A, IL-23, and IL-17A/IL-23 axis in the pathogenesis of age-associated inflammation in AD patients. Result: IL-23/IL-17A axis, is an important factor participate in the pathogenesis of age-associated inflammation. The genetic variations and microbial infection can be considered as the most important candidates to induce AD via upregulation of IL-17A. IL-17A also deteriorates AD via induction by amyloid-beta. IL-17A participates in the induction of AD by increasing neutrophils infiltration to brain, induction of neuroinflammation, increase in FASL, and amyloid-beta deposition as well as activation of microglia. Conclusions: Due to the important roles played by IL-23/IL-17A axis in AD pathogenesis, it can be considered as a target for immunotherapy against AD.

Item Type: Article
Keywords: Aging Alzheimer IL-17A IL-23 inflammation amyloid-beta-peptide ifn-gamma interleukin-17 family receptor cells infection activation increases roles immunotherapy Immunology
Page Range: pp. 812-822
Journal or Publication Title: Immunological Investigations
Journal Index: ISI
Volume: 47
Number: 8
Identification Number: https://doi.org/10.1080/08820139.2018.1504300
ISSN: 0882-0139
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/3006

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