Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

The roles of toll like receptor 3, 7 and 8 in allergic rhinitis pathogenesis

(2018) The roles of toll like receptor 3, 7 and 8 in allergic rhinitis pathogenesis. Allergologia Et Immunopathologia. pp. 503-507. ISSN 0301-0546

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Abstract

Allergic rhinitis, as an allergic and nasal hypersensitivity disease, is associated with the inflammation of nasal mucosa. It appears that innate immune receptors are the important risk factors in the pathogenesis of the inflammatory disease. Toll-like receptors (TLRs) are the most important receptors of innate immunity; their crucial roles in the recognition of allergens and subsequently pathogenesis of allergic diseases have been evaluated recently. TLR3, 7 and 8 are the intracellular members of the innate immune receptors and recognize intracellular single and double strand RNAs. This review article collected the investigations regarding the roles of TLR3, 7 and 8 in the allergic rhinitis pathogenesis. (C) 2018 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.

Item Type: Article
Keywords: Allergic rhinitis TLR3 TLR7 TLR8 Inflammation innate immune-responses plays significant roles nasal epithelial-cells hepatitis-b infection agonist virus tlr3 cytokines target Allergy Immunology
Page Range: pp. 503-507
Journal or Publication Title: Allergologia Et Immunopathologia
Journal Index: ISI
Volume: 46
Number: 5
Identification Number: https://doi.org/10.1016/j.aller.2017.09.026
ISSN: 0301-0546
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4240

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