Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Analysis of Th22, Th17 and CD4(+) cells co-producing IL-17/IL-22 at different stages of human colon cancer

(2018) Analysis of Th22, Th17 and CD4(+) cells co-producing IL-17/IL-22 at different stages of human colon cancer. Biomedicine & Pharmacotherapy. pp. 1101-1106. ISSN 0753-3322

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Abstract

T-helper (Th) 22 cells are involved in the immunopathogenesis of inflammatory diseases, but their specific role in the immunopathogenesis of cancer is unknown. In this study, we examined the profile of circulating and intratumoral Th17, Th22 and CD4(+) cells co-producing IL-17/IL-22 in colon cancer (CC) patients in relation to tumor staging. Thirty newly diagnosed colon cancer (CC) patients participated in this study. The percentage of Th1 (CD4(+)IFN-gamma+IL-17(-)IL-22(-)), Th17 (CD4(+) IFN-gamma-IL-17(+)IL-22(-)), Th22 (CD4(+)IFN-gamma-IL-17(-)IL-22(+)) and CD4(+) cells co-producing IL-17/IL-22 (CD4(+)IFN-gamma-IL-17(+)IL-22(+)) in the peripheral blood, tumor and paratumor tissues was assessed by multicolor flow cytometry. The percentage of circulating Th17 and Th22 cells was significantly increased in CC patients compared to that in healthy controls (HCs). In addition, the percentage of infiltrating Th1, Th17, Th22 and CD4(+) cells co-producing IL-17/IL-22 was significantly increased in the tumor tissues compared to that in the parartumor tissues. Furthermore, we also found that the percentage of circulating and intratumoral Th17, Th22 and CD4(+) cells co-producing IL-17/IL-22 was higher in advanced stages than in early stages. Our findings revealed that Th17, Th22 and CD4(+) cells co-producing IL-17/IL-22 were accumulated in colon cancer tissues and may be involved in the tumor development and progression. A better comprehension of the immunopathogenesis of Th17, Th22 and CD4(+)cells co-producing IL-17/IL-22 in colon cancer patients would help in the development of novel therapies.

Item Type: Article
Keywords: Th22 cells Colon cancer Tumor Paratumor Progression colorectal-cancer interleukin 22 tumor-immunity inflammation progression expression cytokines innate alpha Research & Experimental Medicine Pharmacology & Pharmacy
Page Range: pp. 1101-1106
Journal or Publication Title: Biomedicine & Pharmacotherapy
Journal Index: ISI
Volume: 103
Identification Number: https://doi.org/10.1016/j.biopha.2018.04.147
ISSN: 0753-3322
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4259

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