Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

The effect of exercise preconditioning on stroke outcome in ovariectomized mice with permanent middle cerebral artery occlusion

(2018) The effect of exercise preconditioning on stroke outcome in ovariectomized mice with permanent middle cerebral artery occlusion. Canadian Journal of Physiology and Pharmacology. p. 8. ISSN 0008-4212

Full text not available from this repository.

Official URL: http://apps.webofknowledge.com/InboundService.do?F...

Abstract

Exercise preconditioning has been shown to be effective in improving behavioral and neuropathological indices after cerebral ischemia. We evaluated the effect of exercise preconditioning, 17 beta-estradiol, and their combination on stroke outcome using an experimental model of stroke in ovariectomized (OVX) mice. OVX mice were randomly assigned to 4 groups as follows: control (stroke), exercise (exercise and stroke), estradiol (17 beta-estradiol and stroke), and exercise+estradiol (exercise and 17 beta-estradiol and stroke). Exercise preconditioning was performed on a treadmill 5 days/week, 40 min/day, at a speed of 18 m/min for 4 weeks. 17 beta-estradiol was gavaged (40 mu g/kg per day) for 4 weeks. Stroke was induced by permanent middle cerebral artery occlusion (pMCAO), and neurological deficits were evaluated 1, 2, and 7 days after stroke. Then, the serum concentrations of matrix metalloproteinase-9 (MMP-9) and interleukin-10 (IL-10) and infarct volumes were assessed. Exercise preconditioning and 17 beta-estradiol induced a better outcome compared with the control ischemic mice, which was manifested by decrease in MMP-9, increase in IL-10, diminished infarct volume, and improved neurological deficits. Concomitant administration of 17 beta-estradiol and exercise also significantly improved these parameters. Exercise preconditioning or administration of 17 beta-estradiol alone or in combination before pMCAO induced significant neuroprotection in OVX mice.

Item Type: Article
Keywords: exercise preconditioning estradiol stroke permanent middle cerebral artery occlusion interleukin 10 matrix metalloproteinase-9 brain-barrier dysfunction ischemic-stroke combination therapy physical-activity focal ischemia neurotrophic factor estrogen-receptors sex-differences female rats expression Pharmacology & Pharmacy Physiology
Page Range: p. 8
Journal or Publication Title: Canadian Journal of Physiology and Pharmacology
Journal Index: ISI
Volume: 96
Number: 3
Identification Number: https://doi.org/10.1139/cjpp-2017-0157
ISSN: 0008-4212
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4286

Actions (login required)

View Item View Item