Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Humoral and T cell-mediated immune response against trichomoniasis

(2018) Humoral and T cell-mediated immune response against trichomoniasis. Parasite Immunology. p. 11. ISSN 0141-9838

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Abstract

Trichomonas vaginalis (T.vaginalis) infection leads to the synthesis of specific antibodies in the serum and local secretions. The profile of T.vaginalis-specific antibodies and T cell-mediated immune responses may influence the outcome of infection, towards parasite elimination, persistence or pathological reactions. Studies have indicated that Th1-, Th17- and Th22 cell-related cytokines may be protective or pathogenic, whereas Th2- and Treg cell-related cytokines can exert anti-inflammatory effects during T.vaginalis infection. A number of T.vaginalis-related components such as lipophosphoglycan (TvLPG), -actinin, migration inhibitory factor (TvMIF), pyruvate:ferredoxin oxidoreductase (PFO), legumain-1 (TvLEGU-1), adhesins and cysteine proteases lead to the induction of specific antibodies. T.vaginalis has acquired several strategies to evade the humoral immune responses such as degradation of immunoglobulins by cysteine proteases, antigenic variation and killing of antibody-producing B cells. The characterization of the T.vaginalis-specific antibodies to significant immunogenic molecules and formulation of strategies to promote their induction in vaginal mucosa may reveal their potential protective effects against trichomoniasis. In thisreview, we discuss the current understanding of antibody and T cell-mediated immune responses to T.vaginalis and highlight novel insights into the possible role of immuneresponses in protection against parasite.

Item Type: Article
Keywords: cell-mediated immunity humoral immunity Trichomonas vaginalis trichomoniasis 62 kda proteinase experimental intravaginal trichomoniasis pyruvate-ferredoxin oxidoreductase sexually-transmitted-disease genital-tract infections vaginalis alpha-actinin igg subclass responses nf-kappa-b asymptomatic women secretory products Immunology Parasitology
Page Range: p. 11
Journal or Publication Title: Parasite Immunology
Journal Index: ISI
Volume: 40
Number: 3
Identification Number: https://doi.org/10.1111/pim.12510
ISSN: 0141-9838
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4287

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