Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Serum Levels of IL-6, IL-8, TNF-alpha, and TGF-beta in Chronic HBV-Infected Patients: Effect of Depression and Anxiety

(2018) Serum Levels of IL-6, IL-8, TNF-alpha, and TGF-beta in Chronic HBV-Infected Patients: Effect of Depression and Anxiety. Laboratory Medicine. pp. 41-46. ISSN 0007-5027

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Abstract

Objective: To assess the effects of depression and anxiety on serum cytokine levels in patients with chronic hepatitis B (CHB) infection. Methods: In this cross-sectional study, 60 healthy control individuals and 60 patients with CHB participated after filling out standard questionnaires. We examined their serum interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-alpha, and TGF-beta levels using enzyme-linked immunosorbent assay (ELISA) techniques. Results: In patients with CHB compared with healthy controls, serum levels of IL-8 were significantly increased, whereas IL-6 and TGF-beta levels were significantly decreased. Serum levels of TGF-beta were significantly decreased in the patients with CHB who had mild depression, compared with patients with CHB without depression and with moderate and severe depression. Conclusions: Downregulation of IL-8 and TGF-beta, respectively, is a corresponding mechanism for induction of chronic inflammation in patients with CHB. Depression also seems to induce inflammation via downregulation of TGF-beta in these patients.

Item Type: Article
Keywords: psychiatric diseases chronic HBV infection IL-6 IL-8 TGF-beta TNF-alpha chronic hepatitis-b profile Medical Laboratory Technology
Page Range: pp. 41-46
Journal or Publication Title: Laboratory Medicine
Journal Index: ISI
Volume: 49
Number: 1
Identification Number: https://doi.org/10.1093/labmed/lmx064
ISSN: 0007-5027
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4288

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