Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Heterogeneous effects of cholecystokinin on neuronal response properties in deep layers of rat barrel cortex

(2018) Heterogeneous effects of cholecystokinin on neuronal response properties in deep layers of rat barrel cortex. Somatosensory and Motor Research. pp. 131-138. ISSN 0899-0220

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Abstract

Cholecystokinin (CCK) is one of the most studied neuropeptides in the brain. In this study, we investigated the effects of CCK-8s and LY225910 (CCK2 receptor antagonist) on properties of neuronal response to natural stimuli (whisker deflection) in deep layers of rat barrel cortex. This study was done on 20 male Wistar rats, weighing 230-260g. CCK-8s (300nmol/rat) and LY225910 (1 mu mol/rat) were administered intracerebroventricularly (ICV). Neuronal responses to deflection of principal (PW) and adjacent (AW) whiskers were recorded in the barrel cortex using tungsten microelectrodes. Computer controlled mechanical displacement was used to deflect whiskers individually or in combination at 30ms inter-stimulus intervals. ON and OFF responses for PW and AW deflections were measured. A condition-test ratio (CTR) was computed to quantify neuronal responses to whisker interaction. ICV administration of CCK-8s and LY225910 had heterogeneous effects on neuronal spontaneous activity, ON and OFF responses to PW and/or AW deflections, and CTR for both ON and OFF responses. The results of this study demonstrated that CCK-8s can modulate neuronal response properties in deep layers of rat barrel cortex probably via CCK2 receptors.

Item Type: Article
Keywords: Cholecystokinin LY225910 somatosensory cortex experience-dependent plasticity temporal characteristics network oscillations glutamate release cck receptors integration nucleus system brain modulation Neurosciences & Neurology
Page Range: pp. 131-138
Journal or Publication Title: Somatosensory and Motor Research
Journal Index: ISI
Volume: 35
Number: 2
Identification Number: https://doi.org/10.1080/08990220.2018.1490259
ISSN: 0899-0220
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4299

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