Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Carboplatin liposomal nanoparticles: Preparation, characterization, and cytotoxicity effects on lung cancer in vitro environment

(2018) Carboplatin liposomal nanoparticles: Preparation, characterization, and cytotoxicity effects on lung cancer in vitro environment. International Journal of Polymeric Materials and Polymeric Biomaterials. pp. 367-370. ISSN 0091-4037

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Abstract

The study aimed to encapsulate anticancer drug carboplatin into liposomal nanoparticles by reverse-phase evaporation technique and evaluate its efficacy on lung cancer in vitro environment. Nanoparticles were characterized in terms of size, drug loading efficiency, drug retention capability, and cytotoxicity effects. Nanoscale particles with 67 drug encapsulation efficiency were prepared. Also, high retention capability (drug release equal to 25 after 72 h) of the nanodrug was confirmed. In addition, results of the nanodrug cytotoxicity indicated nanoparticles increased potency of the drug by approximately 90. Findings of the study indicated liposome can be used for carboplatin delivery to lung cancer.

Item Type: Article
Keywords: Carboplatin liposome lung cancer nanotechnology reverse-phase evaporation TC1 delivery-systems Materials Science Polymer Science
Page Range: pp. 367-370
Journal or Publication Title: International Journal of Polymeric Materials and Polymeric Biomaterials
Journal Index: ISI
Volume: 67
Number: 6
Identification Number: https://doi.org/10.1080/00914037.2017.1332624
ISSN: 0091-4037
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4312

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