Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Innate immunity related pathogen recognition receptors and chronic hepatitis B infection

(2017) Innate immunity related pathogen recognition receptors and chronic hepatitis B infection. Molecular Immunology. pp. 64-73. ISSN 0161-5890

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Innate immunity consists of several kinds of pathogen recognition receptors (PRRs), which participate in the recognition of pathogens and consequently activation of innate immune system against pathogens. Recently, several investigations reported that PRRs may also play key roles in the induction/stimulation of immune system related complications in microbial infections. Hepatitis B virus (HBV), as the main cause of viral hepatitis in human, can induce several clinical forms of hepatitis B and also might be associated with hepatic complications such as cirrhosis and hepatocellular carcinoma (HCC). Based on the important roles of PRRs in the eradication of microbial infections including viral infections and their related complications, it appears that the molecules may be a main part of immune responses against viral infections including HBV and participate in the HBV related complications. Thus, this review article has brought together information regarding the roles of PRRs in immunity against HBV and its complications.

Item Type: Article
Keywords: Hepatitis B virus (HBV) Pathogen recognition receptors Cirrhosis Hepatocellular carcinoma Innate immunity mannose-binding lectin blood mononuclear-cells cyclic-di-gmp plasmacytoid dendritic cells nonparenchymal liver-cells chronic hbv infection natural-killer-cells toll-like receptors nod-like receptors c-type lectins Biochemistry & Molecular Biology Immunology
Page Range: pp. 64-73
Journal or Publication Title: Molecular Immunology
Journal Index: ISI
Volume: 90
Identification Number:
ISSN: 0161-5890
Depositing User: مهندس مهدی شریفی

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