Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

In vivo study of antifungal effects of low-molecular-weight chitosan against Candida albicans

(2017) In vivo study of antifungal effects of low-molecular-weight chitosan against Candida albicans. Journal of Oral Science. pp. 425-430. ISSN 1343-4934

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Abstract

This study investigated the antifungal effects of low-molecular-weight chitosan solution on Candida albicans in denture stomatitis in comparison with nystatin suspension. This randomized, single-blind clinical trial included 40 patients diagnosed with denture stomatitis. Patients were divided into two groups, wherein one was treated with chitosan and the other with nystatin for 2 weeks. Changes in the erythematous area were recorded during and after treatment. A palatal smear was obtained for each patient before and after treatment to determine the number of blastospores and mycelia of C. albicans. The results were compared using the Mann Whitney U test, revealing that the chitosan solution significantly decreased the erythematous surface area, burning sensation, time required for clinical improvement, and number of blastospores and mycelia. The antifungal efficacy of chitosan along with its inherent biocompatibility makes it a promising candidate for use as an antifungal mouthwash.

Item Type: Article
Keywords: Candida albicans chitosan oral infection denture stomatitis water-soluble chitosan denture stomatitis antibacterial activity antimicrobial activity delivery chitin colonization derivatives hydrogels efficacy Dentistry, Oral Surgery & Medicine Materials Science
Page Range: pp. 425-430
Journal or Publication Title: Journal of Oral Science
Journal Index: ISI
Volume: 59
Number: 3
Identification Number: https://doi.org/10.2334/josnusd.16-0295
ISSN: 1343-4934
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4352

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