Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

The role of transient receptor potential vanilloid type 1 in unimodal and multimodal object recognition task in rats

(2017) The role of transient receptor potential vanilloid type 1 in unimodal and multimodal object recognition task in rats. Pharmacological Reports. pp. 526-531. ISSN 1734-1140

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Abstract

Background: The role of transient receptor potential vanilloid type 1 (TRPV1) channels in learning and memory processes has recently been recognized. In the present study, the role of this receptor in the multisensory integration process was investigated. Methods: This study was done using 96 male Wistar rats, which were kept in a reverse 12-12 h dark/Iight cycle. Unimodal and multimodal object recognition task was performed by four variations of the spontaneous object recognition (SOR) test including standard SOR, tactile SOR, visual SOR, and cross- modal visual-tactile SOR (CMOR). AMG9810 (selective TRPV1 antagonist) was injected into the right lateral cerebral ventricle prior to sample and choice phases of SOR. A discrimination ratio was calculated to assess the preference of the animal for the novel object. Results: Results demonstrated that administration of AMG9810 prior to the sample phase, as encoding phase, and prior to the choice phase, as retrieval phase, impaired discrimination between the novel and the familiar objects in all standard SOR, tactile SOR, visual SOR, and CMOR tasks (all p < 0.05). Conclusion: The results of this study showed that TRPV1 receptors might be implicated in both unimodal and cross-modal encoding of information in rats. (C) 2017 Published by Elsevier Sp. z o.o. on behalf of Institute of Pharmacology, Polish Academy of Sciences.

Item Type: Article
Keywords: TRPV1 Multisensory integration Learning Memory hippocampal-lesions synaptic plasticity perirhinal cortex trpv1 antagonist spatial memory capsaicin channel schizophrenia consolidation integration Pharmacology & Pharmacy
Page Range: pp. 526-531
Journal or Publication Title: Pharmacological Reports
Journal Index: ISI
Volume: 69
Number: 3
Identification Number: https://doi.org/10.1016/j.pharep.2017.01.025
ISSN: 1734-1140
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4371

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