Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Bio-effectiveness of the main flavonoids of Achillea millefolium in the pathophysiology of neurodegenerative disorders - a review

(2017) Bio-effectiveness of the main flavonoids of Achillea millefolium in the pathophysiology of neurodegenerative disorders - a review. Iranian Journal of Basic Medical Sciences. pp. 604-612. ISSN 2008-3866

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Abstract

The Achillea millefolium L. (Yarrow) is a common herb which is widely being used, worldwide. Achillea is being used for treatment of many disorders since centuries. It is considered safe for supplemental use and flavonoids such as kaempferol, luteolin and apigenin are of main constituents present in Achillea. Most of both antioxidant and anti-inflammatory properties of this herb have been attributed to its flavonoid content. Oxidative and inflammatory processes play important roles in pathogenesis of neurodegenerative diseases. Present review was aimed to review the latest literature evidences regarding application of Achillea and/or its three main flavonoid constituents on epilepsy, Alzheimer's disease, multiple sclerosis, Parkinson's disease and stroke.

Item Type: Article
Keywords: Achillea millefolium Flavonoids Medicinal Neurodegenerative-disease Plants experimental autoimmune encephalomyelitis co-ultramicronized palmitoylethanolamide/luteolin differentiated pc12 cells central-nervous-system alzheimers-disease multiple-sclerosis oxidative stress in-vitro cognitive impairment parkinsons-disease Research & Experimental Medicine Pharmacology & Pharmacy
Page Range: pp. 604-612
Journal or Publication Title: Iranian Journal of Basic Medical Sciences
Journal Index: ISI
Volume: 20
Number: 6
Identification Number: https://doi.org/10.22038/ijbms.2017.8827
ISSN: 2008-3866
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4375

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