Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Preparation, Characterization and Cytotoxic Effects of Pegylated Nanoliposomal Containing Carboplatin on Ovarian Cancer Cell Lines

(2017) Preparation, Characterization and Cytotoxic Effects of Pegylated Nanoliposomal Containing Carboplatin on Ovarian Cancer Cell Lines. Indian Journal of Clinical Biochemistry. pp. 230-234. ISSN 0970-1915

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Abstract

Carboplatin is a chemotherapeutic agent used against various malignancies such as ovarian carcinoma. The aim of this study is to improve the therapeutic efficacy of carboplatin using pegylated liposomal nanocarriers. Nanoparticles were synthesized using thin film hydration technique and characterized for shape morphology, particle size, zeta potential and drug-release properties. In the next step, A2780S and A2780CP ovarian cancer cell lines were used to determine the efficacy of nanodrug by MTT assay. The particle size and zeta potential of nanodrug were measured 244.3 +/- 19.6 nm and -22.9 +/- 1.7 mV, respectively. High encapsulation capacity (78.6 +/- 3.7 ) confirmed the efficiency of technique. The cytotoxicity results also showed that nanodrug compared to free drug improve the efficacy of carboplatin against both A2780S (P < 0.01) and A2780CP (P < 0.05) cell lines. In conclusion, the findings of our study suggested pegylated liposomal nanocarriers are proper for carboplatin delivery to ovarian cancer cell lines A2780S and A2780CP.

Item Type: Article
Keywords: Ovarian cancer Carboplatin Liposome Cellular uptake delivery exposure drugs Biochemistry & Molecular Biology
Page Range: pp. 230-234
Journal or Publication Title: Indian Journal of Clinical Biochemistry
Journal Index: ISI
Volume: 32
Number: 2
Identification Number: https://doi.org/10.1007/s12291-016-0596-3
ISSN: 0970-1915
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4381

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