Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Effect of TPMPA (GABA(C) receptor antagonist) on neuronal response properties in rat barrel cortex

(2017) Effect of TPMPA (GABA(C) receptor antagonist) on neuronal response properties in rat barrel cortex. Somatosensory and Motor Research. pp. 108-115. ISSN 0899-0220

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Abstract

GABA(C) receptors are ligand-gated chloride channels and have important roles in some neurological functions like vision. Recent investigations demonstrated that these receptors are also expressed in the somatosensory cortex. In this study, we investigated the effect of (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA) (GABA(C) receptor antagonist) on the properties of the neuronal response to natural stimuli (whisker deflection) in deep layers of rat barrel cortex. Twenty-eight male Wistar rats, weighing 230-260g, were used in this study. TPMPA (100mol/rat) was administered intracerebroventricularly (ICV). Neuronal responses to deflection of principal (PW) and adjacent (AW) whiskers were recorded in barrel cortex using tungsten microelectrodes. A computer-controlled mechanical displacement was used to deflect whiskers individually or in combination at 30ms inter-stimulus intervals. ON and OFF responses for PW and AW deflections were measured. A condition-test ratio (CTR) was computed to quantify neuronal responses to whisker interactions. Our data suggest that ICV administration of TPMPA increased neuronal spontaneous activity, ON and OFF responses to PW, and/or AW deflections. However, CTR for neither ON nor OFF responses changed following TPMPA administration. The results of this study demonstrated that inhibition of GABA(C) receptors by TPMPA can modulate neuronal response properties in rat barrel cortex.

Item Type: Article
Keywords: Electrophysiology GABA(C) receptor somatosensory cortex experience-dependent plasticity temporal characteristics network oscillations mediated inhibition tiger salamander field properties integration retina mouse transmission Neurosciences & Neurology
Page Range: pp. 108-115
Journal or Publication Title: Somatosensory and Motor Research
Journal Index: ISI
Volume: 34
Number: 2
Identification Number: https://doi.org/10.1080/08990220.2017.1317240
ISSN: 0899-0220
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4432

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