Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Effects of naringin on physical fatigue and serum MMP-9 concentration in female rats

(2017) Effects of naringin on physical fatigue and serum MMP-9 concentration in female rats. Pharmaceutical Biology. pp. 423-427. ISSN 1388-0209

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Abstract

Context: Oxidative stress has a critical role in the development of physical fatigue and activation of matrix metalloproteinases-9 (MMP-9). Naringin (Nar) is a bioflavonoid that has antioxidant activity and suppresses MMP-9 expression. Objective: The present study evaluates the anti-fatigue activity of Nar on physical fatigue and serum MMP-9 concentration in rats. Materials and methods: Fifty female Wistar rats were randomly divided into five groups (n = 10); a control group, vehicle group and three Nar treatment groups. The Nar treated groups received different doses of Nar (40, 80 and 160 mg/kg/day) for 30 days. On the 30th day, rats were sacrificed immediately after exhaustive swimming test. Serum MMP-9 concentration and several biochemical parameters related to fatigue were measured. Results: Exhaustive swimming time in the Nar-80 group significantly increased 1.78-, 1.53-, 1.5- and 1.3-fold compared with the control, vehicle, Nar-40 and Nar-160 groups, respectively. In addition, exhaustive swimming time in the Nar-160 group significantly increased 1.36-fold compared with the control group. Nar-80 significantly decreased LDH activity by 60.45 and 57.47 compared with the vehicle and control groups, respectively. Furthermore, Nar-80 and Nar-160 increased blood glucose levels by 19.56 and 18.38 compared with the control group, respectively. Nar-80 and Nar-160 significantly decreased serum MMP-9 concentration by 61.57 and 83.39 compared with the control group, respectively. Conclusion: Based on our data, Nar has anti-fatigue effects which may be attributed to its property in modulating energy metabolism and reducing serum MMP-9 concentration. Thus, Nar may be a promising agent for the treatment of physical fatigue.

Item Type: Article
Keywords: Lactate dehydrogenase glucose exhaustive swimming test human skeletal-muscle oxidative stress matrix metalloproteinases anti-fatigue human glioblastoma signaling pathway wistar rats in-vitro exercise expression Plant Sciences Medical Laboratory Technology Pharmacology & Pharmacy
Page Range: pp. 423-427
Journal or Publication Title: Pharmaceutical Biology
Journal Index: ISI
Volume: 55
Number: 1
Identification Number: https://doi.org/10.1080/13880209.2016.1244553
ISSN: 1388-0209
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4440

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