Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

The Role of Interleukin-17A (IL-17A) in Depression

(2016) The Role of Interleukin-17A (IL-17A) in Depression. Iranian Red Crescent Medical Journal. p. 4. ISSN 2074-1804

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Context: The aim of this review was to address the recent data regarding the role of IL-17A in the pathogenesis of depression and its complications, such as cancer. Evidence Acquisition: This review article summarizes the recent data on the role of IL-17A in depression, using the PubMed and Google Scholar databases. Results: It has been documented that depression may alter the immune response via unknown mechanism/s. It is possible that immune responses and depression are linked via several molecules, including cytokines. IL-17A, a pro-inflammatory cytokine, participates in the pathogenesis of several inflammatory-based diseases, such as autoimmunity. Conclusions: Due to the comorbidity of depression and chronic inflammatory processes, and depression's effect on the immune system, it may be hypothesized that the IL-17A cytokine plays a key role in the pathogenesis of depression.

Item Type: Article
Keywords: Depression IL-17A Th17 th17 cells hepatocellular-carcinoma antidepressant treatment rheumatoid-arthritis tumor progression plasma-levels cytokines infection differentiation inflammation General & Internal Medicine
Page Range: p. 4
Journal or Publication Title: Iranian Red Crescent Medical Journal
Journal Index: ISI
Volume: 18
Number: 12
Identification Number:
ISSN: 2074-1804
Depositing User: مهندس مهدی شریفی

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