Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Hyperforin-loaded gold nanoparticle alleviates experimental autoimmune encephalomyelitis by suppressing Th1 and Th17 cells and upregulating regulatory T cells

(2016) Hyperforin-loaded gold nanoparticle alleviates experimental autoimmune encephalomyelitis by suppressing Th1 and Th17 cells and upregulating regulatory T cells. Nanomedicine-Nanotechnology Biology and Medicine. pp. 1961-1971. ISSN 1549-9634

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Abstract

Hyperforin an herbal compound, is commonly used in traditional medicine due to its anti-inflammatory activities. The aim of this study was to use a hyperforin loaded gold nanoparticle ( Hyp-GNP) in the treatment of experimental autoimmune encephalomyelitis ( EAE) an animal model of multiple sclerosis ( MS). Hyp-GNP and hyperforin significantly reduced clinical severity of EAE, which was accompanied by a decrease in the number of inflammatory cell infiltration in the spinal cord. Additionally, treatment with Hyp-GNP significantly inhibited disease-associated cytokines as well as an increase in the anti-inflammatory cytokines in comparison to all groups including the free-hyp group. Furthermore, hyperforin and Hyp-GNP inhibited the differentiation of Th1 and Th17 cells while promoting Treg and Th2 cell differentiation via regulating their master transcription factors. The current study demonstrated the although, free-hyp improved clinical and laboratory data Hyp-GNP is significantly more efficient than free hyperforin in the treatment of EAE. (C) 2016 Elsevier Inc. All rights reserved.

Item Type: Article
Keywords: Hyperforin Multiple sclerosis Experimental autoimmune encephalomyelitis (EAE) Myelin oligodendrocyte glycoprotein (MOG) Gold nanoparticle st-johns-wort nf-kappa-b multiple-sclerosis in-vivo differentiation inflammation cytokines disease antioxidant model Science & Technology - Other Topics Research & Experimental Medicine
Page Range: pp. 1961-1971
Journal or Publication Title: Nanomedicine-Nanotechnology Biology and Medicine
Journal Index: ISI
Volume: 12
Number: 7
Identification Number: https://doi.org/10.1016/j.nano.2016.04.001
ISSN: 1549-9634
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4456

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