Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Preparation, characterization, and cytotoxic effects of liposomal nanoparticles containing cisplatin: an in vitro study

(2016) Preparation, characterization, and cytotoxic effects of liposomal nanoparticles containing cisplatin: an in vitro study. Chemical Biology & Drug Design. pp. 568-573. ISSN 1747-0277

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Abstract

Cisplatin is a chemotherapeutic agent used for treating various malignancies. The study aimed to prepare pegylated liposomal cisplatin and evaluate its efficacy against human breast cancer cell line MCF-7. Drug-loaded nanoparticles were synthesized by reverse phase evaporation technique. The study is highlighted by extensive characterization of nanoparticles in terms of nanoparticle morphology, type of drug entrapment, cisplatin retention capability, and cytotoxicity effects. The size, size distribution, and zeta potential of nanodrug were estimated 142nm, 0.33, and -22mV, respectively. Drug-loading efficiency was equal to 48 that occurred physically. Furthermore, high retention capability (39 of drug was released after 72h) with significantly enhanced cytotoxicity of nanodrug (1.75 times more than the standard drug) confirmed the potency of liposomal nanoparticles as proper cisplatin carrier.

Item Type: Article
Keywords: atomic force microscopy cisplatin cytotoxicity drug delivery pegylated liposome cell lung-cancer cervical-cancer delivery formulation carcinoma toxicity efficacy release trials Biochemistry & Molecular Biology Pharmacology & Pharmacy
Page Range: pp. 568-573
Journal or Publication Title: Chemical Biology & Drug Design
Journal Index: ISI
Volume: 88
Number: 4
Identification Number: https://doi.org/10.1111/cbdd.12786
ISSN: 1747-0277
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4457

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