Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Effects of Dimethyl Sulfoxide on Neuronal Response Characteristics in Deep Layers of Rat Barrel Cortex

(2016) Effects of Dimethyl Sulfoxide on Neuronal Response Characteristics in Deep Layers of Rat Barrel Cortex. Basic and Clinical Neuroscience. pp. 213-220. ISSN 2008-126X

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Abstract

Introduction: Dimethyl sulfoxide (DMSO) is a chemical often used as a solvent for water-insoluble drugs. In this study, we evaluated the effect of intracerebroventricular (ICV) administration of DMSO on neural response characteristics (in 1200-1500 mu m depth) of the rat barrel cortex. Methods: DMSO solution was prepared in 10 v/v concentration and injected into the lateral ventricle of rats. Neuronal spontaneous activity and neuronal responses to deflection of the principal whisker (PW) and adjacent whisker (AW) were recorded in barrel cortex. A condition test ratio (CTR) was used to measure inhibitory receptive fields in barrel cortex. Results: The results showed that both PW and AW evoked ON and OFF responses, neuronal spontaneous activity and inhibitory receptive fields did not change following ICV administration of DMSO. Conclusion: Results of this study suggest that acute ICV administration of 10 DMSO did not modulate the electrophysiological characteristics of neurons in the l deep ayers of rat barrel cortex.

Item Type: Article
Keywords: DMSO Electrophysiology Somatosensory cortex Rats experience-dependent plasticity temporal characteristics ventral hippocampus dimethylsulfoxide integration currents dmso cell patterns system Neurosciences & Neurology
Page Range: pp. 213-220
Journal or Publication Title: Basic and Clinical Neuroscience
Journal Index: ISI
Volume: 7
Number: 3
Identification Number: https://doi.org/10.15412/j.Bcn.03070306
ISSN: 2008-126X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4480

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