Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Expression of TRPV1 Receptors Increased in Hippocampus Following Pentylenetetrazole-Induced Kindling in Male Rats

(2016) Expression of TRPV1 Receptors Increased in Hippocampus Following Pentylenetetrazole-Induced Kindling in Male Rats. Archives of Neuroscience. p. 4. ISSN 2322-3944

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Abstract

Background: The exact pathogenesis of epilepsy is not clear well. Recent studies showed the possible involvement of transient receptor potential vanilloid type 1 (TRPV1) receptors in this disease. Objectives: The aim of this study was to measure the expression of TRPV1 receptors in hippocampus following pentylenetetrazole (PTZ)-induced kindling in male rats. Materials and Methods: In this experimental study, 14 male Wistar rats were allocated into two groups of experimental and control (seven rats in each group). The kindling group received a subconvulsive dose of PTZ (35 mg/kg, intraperitoneally) every 48 hours for 15 sessions, while the control rats were injected with an equal dose of saline. At the end of the injections, rats were decapitated, and their brains were removed. TRPV1 receptor expression in hippocampus region was assessed by real-time polymerase chain reaction method. Results: The results of the current study showed that expressions of TRPV1 receptors were increased in hippocampus following PTZ-induced kindling in male rats. Conclusions: Since the expression of TRPV1 receptors increased in hippocampus of epileptic rats, the TRPV1 receptors may be good candidates for epilepsy treatment.

Item Type: Article
Keywords: Kindling Pentylenetetrazole Hippocampus TRPV1 temporal-lobe epilepsy vanilloid receptors anandamide sclerosis channels seizure memory Neurosciences & Neurology
Page Range: p. 4
Journal or Publication Title: Archives of Neuroscience
Journal Index: ISI
Volume: 3
Number: 3
Identification Number: https://doi.org/10.5812/archneurosci.35459
ISSN: 2322-3944
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4482

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