Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Significant roles played by interleukin-10 in outcome of pregnancy

(2016) Significant roles played by interleukin-10 in outcome of pregnancy. Iranian Journal of Basic Medical Sciences. pp. 119-124. ISSN 2008-3866

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Abstract

Imbalanced immune responses against fetus alloantigens can lead to abnormality in pregnancy. Interleukin-10 (IL-10) plays key roles in regulation of immune responses against self and foreign antigens to induce tolerance to these antigens. Therefore, alteration in expression of IL-10 during pregnancy may result in several pathologic conditions such as preterm labor. IL-10 leads to a normal pregnancy via several molecular mechanisms including development of tolerogenic dendritic cells, T regulatory lymphocytes and activation of the JAK1/STAT3 pathway in the target cells. This review has collected recent data regarding the status of IL-10 expression during term and preterm deliveries and also its molecular mechanisms that lead to a normal pregnancy.

Item Type: Article
Keywords: IL-10 Preterm delivery Term delivery hepatitis-b infection preterm birth gene polymorphisms iranian patients inflammatory cytokines transcription-3 stat3 promoter polymorphism signal transducer ifn-gamma il-10 Research & Experimental Medicine Pharmacology & Pharmacy
Page Range: pp. 119-124
Journal or Publication Title: Iranian Journal of Basic Medical Sciences
Journal Index: ISI
Volume: 19
Number: 2
ISSN: 2008-3866
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4511

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