Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Investigation of adsorption kinetic of Doxorubicin onto iron oxide magnetic nanoparticles functionalized with poly(acrylic acid)/Allyl Alchohol

(2016) Investigation of adsorption kinetic of Doxorubicin onto iron oxide magnetic nanoparticles functionalized with poly(acrylic acid)/Allyl Alchohol. International Journal of Medical Research & Health Sciences. pp. 88-93. ISSN 2319-5886

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Abstract

The study aimed to prepare iron oxide magnetic nanoparticles(MNPs) loaded with anticancer drug Doxorubicin (DOX) in order to evaluate the adsorption isotherms and adsorption kinetic of particles. Nanoparticles were prepared by a reduction-precipitation method and coated with poly(acrylic acid)/Allyl Alchohol as a pH-sensitive co-polymer followed by loading with DOX. They were characterized by FTIR, XRD and TEM techniques. Shapely nanoparticles with the size of 27 nm and loading efficiency of 90 were produced. Also it was cleared that DOX adsorption onto MMNP follows pseudo first-order kinetics. Finally, the proper results of study suggested evaluating the efficacy of nanoparticles against a cancer cell line in vitro environment.

Item Type: Article
Keywords: Drug delivery Functionalized magnetic nanoparticles DOX kinetic study cancer-therapy drug-delivery Research & Experimental Medicine
Page Range: pp. 88-93
Journal or Publication Title: International Journal of Medical Research & Health Sciences
Journal Index: ISI
Volume: 5
Number: 9
ISSN: 2319-5886
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4520

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