Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

DNA Methylation and microRNA patterns are in association with the expression of BRCA1 in ovarian cancer

(2016) DNA Methylation and microRNA patterns are in association with the expression of BRCA1 in ovarian cancer. Cellular and Molecular Biology. pp. 16-23. ISSN 0145-5680

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Abstract

Ovarian cancer is the sixth most prevalent cancer in women and is considered the most lethal gynecological malignancy. It can be inherited as a familial disease but also has a strong spontaneous occurrence. Although the disease is associated with genome instability brought on by genetics and environmental factors there is evidence that mutations in the gene encoding for the breast cancer type 1 susceptibility protein (BRCA1) or its down-regulation are involved in its development. Down-regulation of BRCA1 expression by hypermethylation of its promoter may account for some cases of ovarian cancer but this does not explain the cause of the majority of the disease. This review explores the role of BRCA1 promoter hypermethylation and micro-RNAs (miRNA) involved in the regulation of BRCA1 and their role in ovarian cancer development as well as some of the exciting discoveries which could lead to targeting miRNA with a view to restoring BRCA1 expression in diseased tissues.

Item Type: Article
Keywords: Ovarian cancer BRCA1 Hypermethylation Micro-RNA negative breast-cancer promoter methylation sporadic breast multiple genes tumors women risk biogenesis genome region Biochemistry & Molecular Biology Cell Biology
Page Range: pp. 16-23
Journal or Publication Title: Cellular and Molecular Biology
Journal Index: ISI
Volume: 62
Number: 1
ISSN: 0145-5680
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4539

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