Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Role of galectin-3 in the pathogenesis of bladder transitional cell carcinoma

(2015) Role of galectin-3 in the pathogenesis of bladder transitional cell carcinoma. Human Immunology. pp. 770-774. ISSN 0198-8859

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Galectins constitute an evolutionary conserved family that binds to B-galactosides. There is growing evidence that galectins are implicated in essential biological processes such as cellular communication, inflammation, differentiation and apoptosis. Galectin-3 is one of the best-known galectins, which is found in vertebrates. Galectin-3 has been shown to be expressed in some cell lines and plays important roles in several physiological and pathological processes, including cell adhesion, cell activation and chemoattraction, cell cycle, apoptosis, cell growth, and differentiation. Moreover, this galectin is of interest due to its involvement in regulation of cancer. Changes in galectin-3 expression are commonly seen in cancerous and pre-cancerous conditions and galectin-3 may be involved in the regulation of cancer cell activities that contribute to tumourigenesis, cancer progression and metastasis. Finally, galectin-3 seems to be involved in cell events in tumor microenvironment, and therefore it could be considered as a target in transitional cell carcinoma therapies. This review aims to describe recent progress in understanding the role of galectin-3 in cancer biology, with emphasis on bladder tumor progression and metastasis. (C) 2015 Published by Elsevier Inc. on behalf of American Society for Histocompatibility and Immunogenetics.

Item Type: Article
Keywords: Bladder cancer TCC Galectin-3 Tumor cancer progression serum galectin-3 differential expression monoclonal-antibodies therapeutic target tumor progression advanced melanoma prostate-cancer gastric-cancer apoptosis Immunology
Page Range: pp. 770-774
Journal or Publication Title: Human Immunology
Journal Index: ISI
Volume: 76
Number: 10
Identification Number:
ISSN: 0198-8859
Depositing User: مهندس مهدی شریفی

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