Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Lack of Correlation Between the CCR5-Delta 32 Mutation and Acute Myeloid Leukemia in Iranian Patients

(2015) Lack of Correlation Between the CCR5-Delta 32 Mutation and Acute Myeloid Leukemia in Iranian Patients. Indian Journal of Hematology and Blood Transfusion. pp. 29-31. ISSN 0971-4502

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Abstract

Chemokines and their receptors are crucially important in the pathogenesis of acute myeloblastic leukemia (AML). The CC chemokine receptor 5 (CCR5) is a specific chemokine receptor for CC chemokine ligand 3 (CCL3), CCL4 and CCL5 which all play key roles in identifying cancer properties and localization of leukemia cells. It has been demonstrated that the known mutation in CCR5 gene (CCR5-Delta 32) leads to mal-expression of the receptor and affect its function. The aim of this study was to determine the rate of CCR5-Delta 32 mutation within Iranian AML patients. In this study, blood samples were obtained from 60 AML patients and 300 healthy controls. The CCR5-Delta 32 mutation was evaluated using Gap-PCR technique. Our results showed that CCR5-Delta 32 mutation was not found in the patients, while three out of the controls had hetrozygotic form of this mutation. The rest of studied samples had the wild form of the gene. According to these findings, it can probably be concluded that the CCR5-Delta 32 is not associated with susceptibility to AML in Iranian patients.

Item Type: Article
Keywords: CCR5-D32 mutation Acute myeloblastic leukemia Chemokine increased circulating levels multiple-sclerosis polymorphism gene susceptibility association inhibition cxcl12 cells ccr2 Hematology
Page Range: pp. 29-31
Journal or Publication Title: Indian Journal of Hematology and Blood Transfusion
Journal Index: ISI
Volume: 31
Number: 1
Identification Number: https://doi.org/10.1007/s12288-014-0408-y
ISSN: 0971-4502
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4588

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