Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Seminal Levels of Pro-inflammatory (CXCL1, CXCL9, CXCL10) and Homeostatic (CXCL12) Chemokines in Men With Asymptomatic Chlamydia trachomatis Infection

(2014) Seminal Levels of Pro-inflammatory (CXCL1, CXCL9, CXCL10) and Homeostatic (CXCL12) Chemokines in Men With Asymptomatic Chlamydia trachomatis Infection. Jundishapur Journal of Microbiology. p. 4. ISSN 2008-3645

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Abstract

Background: Chemokines play important roles in immune system activation against microbial infections. Objectives: The current study aimed to evaluate seminal levels of CXC chemokines CXCL1, CXCL9, CXCL10 and CXCL12 in Chlamydia trachomatis infected patients. Materials and Methods: The C. trachomatis infection was determined employing Polymerase Chain Reaction (PCR)-based methods. Seminal concentrations of CXCL1, CXCL9, CXCL10 and CXCL12 were measured by Enzyme-Linked Immunosorbent Assay (ELISA). Results: The current study results demonstrated that the semen levels of CXCL1 and CXCL9, but not CXCL10 and CXCL12, significantly increased in C. trachomatis infected patients compared to the healthy controls. Conclusions: Based on the current study results, it may be concluded that both CXCL1 and CXCL9 play more important roles than CXCL10 and CXCL12 in induction of immune responses against C. trachomatis and could possibly be considered as future targets for immunotherapy of C. trachomatis infection.

Item Type: Article
Keywords: Chlamydia trachomatis Chemokine CXCL1 CXCL9 CXCL10 and CXCL12 expression pneumoniae receptors cytokines immunity cells Microbiology
Page Range: p. 4
Journal or Publication Title: Jundishapur Journal of Microbiology
Journal Index: ISI
Volume: 7
Number: 12
Identification Number: https://doi.org/10.5812/jjm.11152
ISSN: 2008-3645
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4604

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