Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Ginger extracts influence the expression of IL-27 and IL-33 in the central nervous system in experimental autoimmune encephalomyelitis and ameliorates the clinical symptoms of disease

(2014) Ginger extracts influence the expression of IL-27 and IL-33 in the central nervous system in experimental autoimmune encephalomyelitis and ameliorates the clinical symptoms of disease. Journal of Neuroimmunology. pp. 80-88. ISSN 0165-5728

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Abstract

The immunomodulatory effects of the IL-27 and IL-33 and the anti-inflammatory effects of ginger have been reported in some studies. The aim was to evaluate the effects of the ginger extract on the expression of IL-27 and IL-33 in a model of experimental autoimmune encephalomyelitis (EAE). In PBS-treated EAE mice the expression of IL-27 P28 was significantly lower whereas the expression of IL-33 was significantly higher than unimmunized control mice. In 200 and 300 mg/kg ginger-treated EAE groups the expression of IL-27 P28 and IL-27 EBI3 was significantly higher whereas the expression of IL-33 was significantly lower than PBS-treated EAE mice. The EAE clinical symptoms and the pathological scores were significantly lower in ginger-treated EAE groups. These results showed that the ginger extract modulates the expression of the IL-27 and IL-33 in the spinal cord of EAE mice and ameliorates the clinical symptoms of disease. (C) 2014 Elsevier B.V. All rights reserved.

Item Type: Article
Keywords: Experimental autoimmune encephalomyelitis Ginger IL-27 IL-33 Clinical symptoms multiple-sclerosis patients zingiber-officinale roscoe ifn-gamma production kappa-b activation t-helper-cells immune-responses therapeutic-efficacy chronic inflammation family-members ror-gamma Immunology Neurosciences & Neurology
Page Range: pp. 80-88
Journal or Publication Title: Journal of Neuroimmunology
Journal Index: ISI
Volume: 276
Number: 1-2
Identification Number: https://doi.org/10.1016/j.jneuroim.2014.08.614
ISSN: 0165-5728
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4608

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