Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Potential roles played by IL-6 in hepatitis B infection

(2014) Potential roles played by IL-6 in hepatitis B infection. Future Virology. pp. 431-438. ISSN 1746-0794

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Hepatitis B is a main disorder of the liver, which is induced by HBV. Hepatitis B can induce liver diseases, such as inflammation, cirrhosis and hepatocellular carcinoma (HCC). Recent studies demonstrated that several patients are unable to eradicate the virus from hepatocytes and develop chronic hepatitis B infections. The main mechanisms responsible for development of chronic hepatitis B and its related cirrhosis as well as HCC are yet to be identified. IL-6 is a proinflammatory cytokine that participates in stimulation of immune responses against viral infections. In addition, it has been documented that IL-6 can play key roles in induction of fibrosis and cancers. Therefore, the aim of this article is to clarify the main roles of IL-6 in stimulation of appropriate immune responses against hepatitis B virus and induction of hepatitis B-dependent cirrhosis as well as HCC.

Item Type: Article
Keywords: cirrhosis HBV hepatitis B hepatocellular carcinoma IL-6 c-reactive protein interleukin-6 gene-expression virus envelope protein chronic liver-disease acute-phase response hepatocellular-carcinoma serum interleukin-6 t-cells molecular-mechanisms multiple-myeloma Virology
Page Range: pp. 431-438
Journal or Publication Title: Future Virology
Journal Index: ISI
Volume: 9
Number: 4
Identification Number:
ISSN: 1746-0794
Depositing User: مهندس مهدی شریفی

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