Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

TLR4 in Toxoplasmosis; friends or foe?

(2014) TLR4 in Toxoplasmosis; friends or foe? Microbial Pathogenesis. pp. 28-32. ISSN 0882-4010

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Toxoplasma species are obligate intracellular protozoan which are responsible for induction of several forms of Toxoplasmosis in humans. The mechanisms responsible for the progression of the prolonged forms of Toxoplasmosis and associated pathologies are yet to be identified. However, previous studies proposed that immunological and genetic parameters may play important roles in the etiology and complexity of Toxoplasmosis. Pathogen recognition receptors (PRRs) recognize microbial antigens and induce immune responses against parasites, including toxoplasma species. Toll like receptors (TLRs) are PRRs which recognize toxoplasma as a pathogenic parasite and activate immune cells. It has been reported that the TLR4 is a critical innate immune cell receptor in toxoplasma detection and subsequently activates immune responses using either MYD88 or TRIF pathways. This review collates recent information regarding the role of TLR4 and its related signaling molecules with Toxoplasmosis. (C) 2014 Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: Toxoplasma Pathogen recognition receptor TLR4 Signaling molecule toll-like receptors gondii-derived heat-shock-protein-70 ocular toxoplasmosis dendritic cells public-health kappa-b macrophages infection activation glycosylphosphatidylinositols Immunology Microbiology
Page Range: pp. 28-32
Journal or Publication Title: Microbial Pathogenesis
Journal Index: ISI
Volume: 69-70
Identification Number:
ISSN: 0882-4010
Depositing User: مهندس مهدی شریفی

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