Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Seminal Levels of IL-10, IL-12, and IL-17 in Men with Asymptomatic Chlamydia Infection

(2014) Seminal Levels of IL-10, IL-12, and IL-17 in Men with Asymptomatic Chlamydia Infection. Inflammation. pp. 122-126. ISSN 0360-3997

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Abstract

Chlamydia trachomatis, as an obligate intracellular parasite, usually causes asymptomatic genital tract infections in both men and women with several complications. The role of C. trachomatis infection in the secretion of a number of interleukins (ILs) from epithelial cells has been established by in vitro studies performed on various cell lines. The aim of this study was to detect the seminal levels of IL-10, IL-12, and IL-17 in men with asymptomatic chlamydia infection. Our case group study included 50 semen samples being PCR-positive for C. trachomatis from 585 semen samples and the ELISA method was applied for detection of IL-10, IL-12, and IL-17. Our results demonstrated that the semen levels of IL-10 and IL-17 were significantly increased, while IL-12 was decreased in C. trachomatis-infected patients. According to these results, it may be concluded that the increased and decreased semen levels of IL-10 and IL-12, respectively, lead to impaired immune responses against C. trachomatis. Increased semen levels of IL-17 may also be associated with the pathogenesis of C. trachomatis infection.

Item Type: Article
Keywords: Chlamydia trachomatis IL-10 IL-12 IL-17 semen trachomatis serovar-e pelvic pain syndrome cellular-immunity tract infections iranian patients cells cytokines responses semen interleukin-6 Cell Biology Immunology
Page Range: pp. 122-126
Journal or Publication Title: Inflammation
Journal Index: ISI
Volume: 37
Number: 1
Identification Number: https://doi.org/10.1007/s10753-013-9719-7
ISSN: 0360-3997
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4659

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