Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Exercise Preconditioning Improves Behavioral Functions following Transient Cerebral Ischemia Induced by 4-Vessel Occlusion (4-VO) in Rats

(2013) Exercise Preconditioning Improves Behavioral Functions following Transient Cerebral Ischemia Induced by 4-Vessel Occlusion (4-VO) in Rats. Archives of Iranian Medicine. pp. 697-704. ISSN 1029-2977

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Background: There are evidence indicating that exercise decreases ischemia/reperfusion injury in rats. Since behavioral deficits are the main outcome in patients after stroke, our study was designed to investigate whether exercise preconditioning improves the acute behavioral functions and also brain inflammatory injury following cerebral ischemia. Methods: Male rats weighing 250-300 g were randomly allocated into five experimental groups. Exercise was performed on a treadmill 30min/day for 3 weeks. Ischemia was induced by 4-vessel occlusion method. Recognition memory was assessed by novel object recognition task (NORT) and step-through passive avoidance task. Sensorimotor function and motor Movements were evaluated by adhesive removal test and ledged beam-walking test, respectively. Brain inflammatory injury was evaluated by histological assessment. Results: In NORT, the discrimination ratio was decreased after ischemia (P < 0.05) and exercise preconditioning improved it in ischemic animals. In the passive avoidance test, a significant reduction in response latency was observed in the ischemic group. Exercise preconditioning significantly decreased the response latency in the ischemic rats (P < 0.001). In the adhesive removal test, latency to touch and remove the sticky labels from forepaw was increased following induction of ischemia (all P < 0.001) and exercise preconditioning decreased these indices compared to the ischemic group (all P < 0.001). In the ledged beam-walking test, the slip ratio was increased following ischemia (P < 0.05). In the ischemia group, marked neuronal injury in hippocampus was observed. These neuropathological changes were attenuated by exercise preconditioning (P < 0.001). Conclusion: Our results showed that exercise preconditioning improves behavioral functions and maintains more viable cells in the dorsal hippocampus of the ischemic brain.

Item Type: Article
Keywords: Cerebral ischemia exercise preconditioning passive avoidance recognition memory object recognition memory locomotor-activity receptor expression reperfusion injury global-ischemia embolic stroke brain-damage deficits model gerbils General & Internal Medicine
Page Range: pp. 697-704
Journal or Publication Title: Archives of Iranian Medicine
Journal Index: ISI
Volume: 16
Number: 12
ISSN: 1029-2977
Depositing User: مهندس مهدی شریفی

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