Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Association of a Polymorphism Within Intron 8 But Not Exon 9 of the Vitamin Receptor in Patients With Multiple Sclerosis of Southeastern Iranian Ethnicity

(2013) Association of a Polymorphism Within Intron 8 But Not Exon 9 of the Vitamin Receptor in Patients With Multiple Sclerosis of Southeastern Iranian Ethnicity. Labmedicine. pp. 215-219. ISSN 0007-5027

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Abstract

Objective: To investigate the association between multiple sclerosis (MS) and polymorphisms in intron 8 and exon 9 of the vitamin D receptor (VDR) gene. Methods: Blood samples were collected from 100 patients with MS and 100 healthy control individuals in ethylenediaminetetraacetic acid (EDTA) tubes. DNA was extracted and analyzed via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) for polymorphisms within the VDR. Demographic data were also collected via a questionnaire designed specifically for this study. Results: Our results showed a significant difference between the A/A genotype and between the A and a alleles of intron 8 of VDR; however, no differences were observed in the other studied alleles. Conclusion: VDR and its functional polymorphisms may be associated with MS.

Item Type: Article
Keywords: multiple sclerosis vitamin D receptor polymorphism gene polymorphisms prevention therapy disease alpha cells risk ccr5 ms Medical Laboratory Technology
Page Range: pp. 215-219
Journal or Publication Title: Labmedicine
Journal Index: ISI
Volume: 44
Number: 3
Identification Number: https://doi.org/10.1309/lm8gljhwing18clb
ISSN: 0007-5027
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4704

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