Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Intrahippocampal administration of D2 but not D-1 dopamine receptor antagonist suppresses the expression of conditioned place preference induced by morphine in the ventral tegmental area

(2013) Intrahippocampal administration of D2 but not D-1 dopamine receptor antagonist suppresses the expression of conditioned place preference induced by morphine in the ventral tegmental area. Neuroscience Letters. pp. 138-143. ISSN 0304-3940

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Abstract

The ventral tegmental area (VTA) as a major source of dopamine neurons projecting to cortical and limbic regions has a crucial role in reward and addiction. The current study assessed the role of D1 and D2 receptors within the dorsal hippocampus (CM) in the expression of conditioned place preference (CPP) by intra-VTA morphine in the rats. In the present study, 160 adult male albino Wistar rats weighing 220-290g were bilaterally implanted by two cannulae into the CA1 and VTA. The CPP paradigm was done and animal displacement, conditioning score and locomotor activity were recorded. For blocking the dopamine D1/D2 receptors in the dorsal hippocampus, SCH23390 (0.02, 0.05, 0.2 and 0.5 mu g per side) or sulpiride (0.25, 0.75, 1.5 and 3 mu g per side) were microinjected into the CA1, just 5 min before the CPP test on the post-conditioning day. All animals received intra-VTA morphine (1 mu g per side) during 3-days conditioning phase. Our results showed that sulpiride (1.5 and 3 mu g) but not SCH23390 in the dorsal hippocampus significantly decreased the expression of CPP induced by intra-VTA morphine (p < 0.001). Intra-CA1 administration of these antagonists alone, in all doses, could not induce CPP. We suggest that D2 receptors in the CA1 region of hippocampus have a key role in the expression of CPP induced by morphine at the level of the VTA and there is a relationship between dopaminergic D2 receptors and opioidergic systems in these areas in reward circuit. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

Item Type: Article
Keywords: Reward Hippocampus Ventral tegmental area Dopaminergic system Opioidergic system Expression Conditioned place preference Rat long-term-memory nucleus-accumbens nitric-oxide rat reward hippocampus acquisition activation plasticity addiction Neurosciences & Neurology
Page Range: pp. 138-143
Journal or Publication Title: Neuroscience Letters
Journal Index: ISI
Volume: 541
Identification Number: https://doi.org/10.1016/j.neulet.2013.03.001
ISSN: 0304-3940
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4707

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