Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Downregulation of CCR5 Expression on the Peripheral Blood CD8(+) T Cells of Southeastern Iranian Patients with Chronic Hepatitis B Infection

(2013) Downregulation of CCR5 Expression on the Peripheral Blood CD8(+) T Cells of Southeastern Iranian Patients with Chronic Hepatitis B Infection. Inflammation. pp. 136-140. ISSN 0360-3997

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Abstract

Studies indicated that CC receptor 5 (CCR5), as a receptor for CC ligand 3, CCL4, and CCL5, plays important roles in the recruitment of T cytotoxic lymphocytes to the liver of chronic HBV (CHB)-infected patients. The main purpose of this study was to investigate the expression levels of CCR5 on the CD8(+) T lymphocytes of CHB patients. This clinical study was performed on 63 CHB patients and 96 healthy controls. Flow cytometric analysis was performed to examine the expression of CCR5 on CD8(+) T cells of CHB patients. Real-time PCR was also used for HBV-DNA quantification. The results of our study demonstrated that CCR5 expressing T cytotoxic cells were decreased significantly in CHB patients in comparison to healthy control. Based on our results, it can be concluded that the percent of CCR5(+)/CD8(+) T cells in Iranian CHB patients is significantly decreased, hence their migration to the infected liver, and HBV eradication from the hepatocytes is disrupted.

Item Type: Article
Keywords: chronic HBV infection CCR5 CD8(+) T lymphocytes ccr5-delta-32 mutation association virus Cell Biology Immunology
Page Range: pp. 136-140
Journal or Publication Title: Inflammation
Journal Index: ISI
Volume: 36
Number: 1
Identification Number: https://doi.org/10.1007/s10753-012-9528-4
ISSN: 0360-3997
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4726

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