Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Serum Levels of IL-6, IL-10, IL-12, IL-17 and IFN-gamma and Their Association with Markers of Bone Metabolism in Vitamin D-Deficient Female Students

(2013) Serum Levels of IL-6, IL-10, IL-12, IL-17 and IFN-gamma and Their Association with Markers of Bone Metabolism in Vitamin D-Deficient Female Students. Inflammation. pp. 164-168. ISSN 0360-3997

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Abstract

Different studies have shown the regulatory effects of vitamin D-3 on the immune system and bone metabolism. Regarding the effects of vitamin D on immune cells and the importance of cytokines on bone metabolism, we assessed the association between serum levels of interleukin (IL)-6, IL-10, IL-12, IL-17 and IFN-gamma cytokines and bone metabolism markers (Ca, P, PTH, ALP) in female students with vitamin D deficiency compared with control group. A total of 100 subjects with 25-hydroxy vitamin D-3 (25-(OH) D-3) deficiency were selected as case and 100 subjects with sufficient 25-hydroxy vitamin D-3 (25-(OH) D-3) were selected as the control group. The serum levels of IL-6, IL-10, IL-12, IL-17 and IFN-gamma were measured by ELISA method. Ionized Ca, PTH, P, ALP levels were also determined in all participants. The results showed a statistically significant positive correlation between the levels of ALP with IFN-gamma, PTH with IL-17 and a significant negative correlation between P with IL-10 in vitamin D deficient group. The results suggest that IL-17, IFN-gamma and IL-10 are important mediators of bone metabolism and vitamin D affect bone metabolism, at least in part, through immune system. In addition, not only vitamin D affect bone metabolism but also modulates immune responses.

Item Type: Article
Keywords: 25-hydroxyl-vitamin D-3 bone metabolism markers cytokines female students nf-kappa-b immune-system osteoclast formation receptor activator circulating levels interleukin-6 cytokines osteoporosis expression resorption Cell Biology Immunology
Page Range: pp. 164-168
Journal or Publication Title: Inflammation
Journal Index: ISI
Volume: 36
Number: 1
Identification Number: https://doi.org/10.1007/s10753-012-9531-9
ISSN: 0360-3997
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4727

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