Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Increased Circulating Levels of SDF-1 (CXCL12) in Type 2 Diabetic Patients Are Correlated to Disease State but Are Unrelated to Polymorphism of the SDF-1 beta Gene in the Iranian Population

(2012) Increased Circulating Levels of SDF-1 (CXCL12) in Type 2 Diabetic Patients Are Correlated to Disease State but Are Unrelated to Polymorphism of the SDF-1 beta Gene in the Iranian Population. Inflammation. pp. 900-904. ISSN 0360-3997

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Abstract

Several environmental and genetic factors are believed to influence the onset of diabetes and its complications. It has also been established that cytokines play a key role in the pathogenesis of type 2 diabetes. Previous studies have revealed that the polymorphism at the stromal-derived factor 1 beta (SDF-1 beta) 3'A regulates the expression of SDF-1 (CXCL12). This study was aimed to explore this polymorphism in parallel with SDF-1 serum levels in type 2 diabetic patients. In this assessment, peripheral blood samples were collected from 200 type 2 diabetic patients and 200 healthy controls. DNA was extracted, and a PCR-RFLP screening was applied to examine the SDF-1 beta 3'A polymorphism. We also applied the ELISA technique to measure serum levels of SDF-1. Our results showed that there were no significant correlations between SDF-1 beta 3'I polymorphism in type 2 diabetic patients when compared to controls. However, our results showed that the serum levels of SDF-1 were significantly increased in the patients when compared to controls. Based on the results of this study, we concluded that SDF-1 beta 3'I polymorphism does not play a role in the pathogenesis of type 2 diabetes but that elevated serum levels of SDF-1 may be important for the etiology of type 2 diabetes but are unrelated to the SDF-1 beta 3'I polymorphism.

Item Type: Article
Keywords: SDF-1 type 2 diabetes polymorphism factor-alpha heat-shock expression sdf-1-alpha gamma Cell Biology Immunology
Page Range: pp. 900-904
Journal or Publication Title: Inflammation
Journal Index: ISI
Volume: 35
Number: 3
Identification Number: https://doi.org/10.1007/s10753-011-9391-8
ISSN: 0360-3997
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4766

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