Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Endocannabinoid System and TRPV1 Receptors in the Dorsal Hippocampus of the Rats Modulate Anxiety-like Behaviors

(2012) Endocannabinoid System and TRPV1 Receptors in the Dorsal Hippocampus of the Rats Modulate Anxiety-like Behaviors. Iranian Journal of Basic Medical Sciences. pp. 795-802. ISSN 2008-3866

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Abstract

Objective(s) Fatty acid is amide hydrolase which reduce endogenous anandamide. Transient receptor potential vanilloid-1 (TRPV1) channels have been reported to have a role in the modulation of anxiety-like behaviors in rodents. In the present study, the effects of either endocannabinoid system or TRPV1 channels and their possible interaction on anxiety-like behaviors of the rats were explored. Materials and Methods Elevated plus-maze test of anxiety was used to induce anxiety. Capsaicin and AMG 9810 as TRPV1 agonist and antagonist respectively were injected into the dorsal hippocampus. URB 597 as selective FAAH inhibitor and AM 251 as CBI receptor selective antagonist were also injected into the dorsal hippocampus. The effect of AMG 9810 on the response of URB 597 was also examined, Results Intra-CA1 injection of URB 597 (0.001, 0.01 and 0.1 mu g/rat) and AMC 9810 (0.003, 0.03 and 0.3 mu g/rat) produced anxiolytic-like effects. Intra-CA1 infusion of capsaicin (0.003, 0.03 and 0.3 mu g/rat) increased the anxiety-related behaviors and AM 251 (0.001, 0.01 and 0.1 mu g/rat) did not significantly change the animals behavior. AMG 9810 at the dose of 0.003 mu g/rat did not change the anxiolytic-like effect of URB 597. Conclusion The results of the present study demonstrated that both endocannabinoid system and TRPV1 receptors may affect anxiety-like behaviors. In addition, it seems that TRPV1 receptors are not involved in the effects of anandamide on anxiety-related behaviors in the CA1 region.

Item Type: Article
Keywords: Anandamide Anxiety CA1 Region Fatty-acid amide hydrolase Rats TRPV Cation Channels acid amide hydrolase dorsolateral periaqueductal gray vanilloid type-1 channels cb1 cannabinoid receptor central-nervous-system in-vitro ventral hippocampus inhibitor urb597 anandamide brain Research & Experimental Medicine Pharmacology & Pharmacy
Page Range: pp. 795-802
Journal or Publication Title: Iranian Journal of Basic Medical Sciences
Journal Index: ISI
Volume: 15
Number: 3
ISSN: 2008-3866
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4769

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