Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

BRCA1 Promoter Methylation Status in Ovarian Cancer

(2012) BRCA1 Promoter Methylation Status in Ovarian Cancer. Labmedicine. pp. 122-124. ISSN 0007-5027

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Abstract

Objective: To evaluate the methylation status of the breast cancer 1, early onset (BRCA1) promoter in ovarian cancer in Iranian patients. Methods: The BRCA1 promoter methylation status of tissue from 60 patients with Mullerian-type ovarian cancer and matched benign ovarian tissue from the same patients was evaluated using bisulfate-modified DNA in methylation-specific polymerase chain reaction (MSP CR) assays. Results: Analysis of BRCA1 promoter methylation status showed that 8 of 60 cases (13) were methylated and 11 of 60 cases (18) were unmethylated. Conclusion: Methylation of the BRCA1 promoter may be a risk factor or cause of ovarian cancer.

Item Type: Article
Keywords: ovarian cancer tumor suppressor methylation Medical Laboratory Technology
Page Range: pp. 122-124
Journal or Publication Title: Labmedicine
Journal Index: ISI
Volume: 43
Number: 4
Identification Number: https://doi.org/10.1309/lm36temluwnzj0tz
ISSN: 0007-5027
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4770

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