Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Association of interleukin-4 polymorphisms with multiple sclerosis in southeastern Iranian patients

(2012) Association of interleukin-4 polymorphisms with multiple sclerosis in southeastern Iranian patients. Annals of Saudi Medicine. pp. 127-130. ISSN 0256-4947

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Abstract

BACKGROUND AND OBJECTIVES: Immune system related factors are important in the pathogenesis of multiple sclerosis (MS). Interleukin 4 (IL-4) as a helper T cell (2TH) cytokine is involved in the regulation of immune responses. Hence, this study was designed to explore the association between MS and polymorphisms in the -590 region of IL-4. DESIGN AND SETTING: A descriptive study at Rafsanjan University of Medical Sciences, Rafsnajan from September 2009 to August 2010. PATIENTS AND METHODS: Blood samples were collected from 100 MS patients and 150 healthy controls on EDTA precoated tubes. DNA was extracted and analyzed for IL-4 polymorphisms using restricted fragment length polymorphism in patients and controls. Demographic data were also collected by a questionnaire that was designed specifically for this study. RESULTS: We observed a significant difference in the C/C, T/C, and T/T genotypes of the -590 region of IL-4 between patients with MS and healthy controls (P <.001). CONCLUSIONS: We conclude that functional polymorphisms of IL-4 possibly play a crucial role in the pathogenesis of MS.

Item Type: Article
Keywords: ccr5-delta-32 mutation gene polymorphisms il-4 asthma alpha cells beta il4 General & Internal Medicine
Page Range: pp. 127-130
Journal or Publication Title: Annals of Saudi Medicine
Journal Index: ISI
Volume: 32
Number: 2
Identification Number: https://doi.org/10.5144/0256-4947.2012.127
ISSN: 0256-4947
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4774

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