Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Anxiogenic effect of CCK8s in the ventral hippocampus of rats: possible involvement of GABA(A) receptors

(2012) Anxiogenic effect of CCK8s in the ventral hippocampus of rats: possible involvement of GABA(A) receptors. Pharmacological Reports. pp. 45-53. ISSN 1734-1140

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Abstract

Cholecystokinin (CCK) as an important neuropeptide in the brain has been implicated in the modulation of anxiety. The effects of this neurotransmitter on anxiety-like behavior in the ventral hippocampus have not been evaluated yet. Moreover, some evidences show a functional interaction between GABA and CCK in the nervous system. Bilateral injections of three doses of CCK8s (0.01, 0.05 and 0.1 mu g/rat) into the ventral hippocampus decreased percentage of open arm time (OAT) and open arm entries (OAE) that arc representative of anxiogenic-like behavior in the elevated plus-maze test of anxiety. Bilateral injections of LY225910, a selective CCK2 receptor antagonist, at the doses of 0.01, 0.1 and 0.5 mu g/rat did not change anxiety-related parameters. Administration of muscimol, a selective GABA(A) receptor agonist, at the doses of 0.001, 0.005 and 0.01 mu g/rat produced dose dependent increase in OAT and OAE indicating an anxiolytic-like effect, while administration of bicuculline, a selective GABA(A) receptor antagonist, at the doses of 0.1, 0.2 and 0.5 mu g/rat decreased OAT and OAE showing that this drug promoted anxious behavior of the rats. Co-administration of bicuculline (0.2 mu g/rat) with CCK8s decreased the anxiogenic effects of CCK8s. Furthermore, co-administration of LY225910 (0.5 mu g/rat) with muscimol increased the anxiolytic effect of muscimol at the dose of 0.001 mu g/rat. The results of this study suggest that both CCK and GABAergic system have important and opposite roles in the modulation of anxiety-like behavior in the ventral hippocampus of rats and they may have a complex interaction in the ventral hippocampus to modulate anxiety-related behavior.

Item Type: Article
Keywords: cholecystokinin GABA anxiety ventral hippocampus rat elevated plus-maze gamma-aminobutyric-acid periaqueductal gray cholecystokinin receptors basolateral amygdala dentate gyrus animal-models b antagonist anxiety modulation Pharmacology & Pharmacy
Page Range: pp. 45-53
Journal or Publication Title: Pharmacological Reports
Journal Index: ISI
Volume: 64
Number: 1
Identification Number: https://doi.org/10.1016/s1734-1140(12)70729-6
ISSN: 1734-1140
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4786

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