Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

IL-10, TNF-alpha and IFN-gamma Levels in Serum and Stomach Mucosa of Helicobacter Pylori-Infected Patients

(2011) IL-10, TNF-alpha and IFN-gamma Levels in Serum and Stomach Mucosa of Helicobacter Pylori-Infected Patients. Iranian Journal of Allergy Asthma and Immunology. pp. 267-271. ISSN 1735-1502

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Abstract

H. pylori is a human pathogen that colonizes the epithelium of the stomach. The host immune response may influence the disease process, where cytokines play important roles in the development of disease. In this study, the concentrations of selected cytokines in the gastric antrum and stomach body mucosa and also in the serum were evaluated. Eighty patients according to their rapid urease test were divided into two groups: H. pylori positive (n=39) and H. pylori-negative (n=41). The concentrations of cytokines in biopsies and serum were determined by ELISA method. The mean TNF-alpha and IFN-gamma levels in the infected group were significantly higher than that of uninfected patients. In contrast, IL-10 level in most patients was undetectable. The mean antral of stomach TNF-alpha and IFN-gamma levels were significantly higher than that of the stomach body. IFN-gamma serum level showed positive correlation with antrum and stomach body levels, whereas no correlation was found in TNF-alpha in different samples. Higher levels of TNF-alpha and IFN-gamma in antral indicate that the colonization of bacteria in the antrum may be higher than stomach body (culture results from two sites support this statement). Increased serum level of IFN-gamma indicates the activation of circulating-T cells against infection. Induced H. pylori-related TNF-alpha is concentrated is gastric mucosa and this pathogen does not cause any significant change in the serum level of this cytokine. Therefore H. pylori by inducing certain inflammatory cytokines but not IL-10 may contribute the process of disease development.

Item Type: Article
Keywords: Helicobacter pylori infection IFN-gamma IL-10 TNF-alpha tumor-necrosis-factor cytokine expression gastric-cancer interferon interleukin-10 responses children cells Allergy Immunology
Page Range: pp. 267-271
Journal or Publication Title: Iranian Journal of Allergy Asthma and Immunology
Journal Index: ISI
Volume: 10
Number: 4
ISSN: 1735-1502
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4794

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