Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Anxiolytic-like Effect of Testosterone in Male Rats: GARA(C) Receptors Are Not Involved

(2011) Anxiolytic-like Effect of Testosterone in Male Rats: GARA(C) Receptors Are Not Involved. Iranian Journal of Basic Medical Sciences. pp. 376-382. ISSN 2008-3866

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Abstract

Objective(s) The effect of testosterone on anxiety-like behaviors has been the subject of some studies. There is evidence that testosterone modulates anxiety via GABA (gama aminobutyric acid) and GABAergic system. The involvement of GABA(C) receptors in those effects of testosterone on anxiety-like behaviors of the rats was investigated in the present study. Materials and Methods A group of rats received subcutaneous injections of testosterone (5, 10 and 20 mg/kg). Two groups of rats received intracerebroventricular injections of either CACA (GABA(C) agonist, 0.125 mu g/rat) or TPMPA (GABA(c) antagonist, 3 microg/rat). following administration of testosterone (5, 10 and 20 mg/kg). After the injections, the rats were submitted to the elevated plus-maze test of anxiety. Results The rats received testosterone alone, showed a decreased in anxiety-like behaviors (P< 0.01). Administration of either CACA or TPMPA did not modify animals' behavior compared to the rats received testosterone alone. Conclusion The results of the present study showed that administration of testosterone induces anxiolytic-like behaviors in the rats and GABA(C) receptors possibly are not involved in the anxiolytic effect of testosterone.

Item Type: Article
Keywords: Anti-Anxiety Agents GABA-C receptors Testosterone Infusions Intraventricular androgenic steroid treatment neuroactive steroids gaba(a) receptors male-mice anxiety behavior specificity antagonist sex Research & Experimental Medicine Pharmacology & Pharmacy
Page Range: pp. 376-382
Journal or Publication Title: Iranian Journal of Basic Medical Sciences
Journal Index: ISI
Volume: 14
Number: 4
ISSN: 2008-3866
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4817

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