Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Vitamin D Receptor Polymorphisms in Type 2 Diabetes in Southeastern Iranian Patients

(2011) Vitamin D Receptor Polymorphisms in Type 2 Diabetes in Southeastern Iranian Patients. Labmedicine. pp. 32-34. ISSN 0007-5027

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Abstract

Background The impact of several environmental and genetic factors on diabetes is well documented The present study was aimed to examine the 2 single nucleotide polymorphisms (SNP) in intron 8 and exon 9 of the vitamin D receptor (VDR) gene in type 2 diabetic patients Material and Methods In this clinical study peripheral blood samples were obtained from 100 type 2 diabetic patients and 100 healthy controls DNA was extracted and polymerase chain reaction restriction fragment length polymorphism (PCR RFLP) was performed to examine 2 SNP polymorphisms within the VDR gene Results Our results showed a significant difference in the Taq1 evaluated genotype of exon 9 in the VDR gene but no significant differences were seen regarding other examined genotypes and alleles Conclusion Based on our results, it can be concluded that VDR and its functional polymorphism in exon 9 may play an important role in the pathogenesis of type 2 diabetes

Item Type: Article
Keywords: VDR polymorphism type 2 diabetes gene polymorphisms 1,25-dihydroxyvitamin d-3 developmental origins bangladeshi asians mellitus nephropathy association population prevention mechanisms Medical Laboratory Technology
Page Range: pp. 32-34
Journal or Publication Title: Labmedicine
Journal Index: ISI
Volume: 42
Number: 1
Identification Number: https://doi.org/10.1309/lmw788xeeyvvlbuv
ISSN: 0007-5027
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4837

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