Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Polymorphisms within Fas gene are not associated with occult hepatitis B virus infection

(2011) Polymorphisms within Fas gene are not associated with occult hepatitis B virus infection. Hepatitis Monthly. pp. 23-26. ISSN 1735-143X

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Background: Occult hepatitis B infection (OBI) is a form of hepatitis in which there is an absence of detectable HBsAg, despite the presence of HBV-DNA in the peripheral blood of patients. It seems that non-effective or attenuated immune system responses against HBV lead to the development of OBI. Previous studies showed that the Fas/Fas ligand (FasL) system is an important death signaling pathway that is used by cytotoxic T lymphocytes to eradicate HBV from the liver. Objectives: To investigate polymorphisms in the -670 region of the Fas gene in those with OBI. Patients and Methods: The plasma samples from 3700 blood donors were tested for HBsAg and anti-HBs by ELISA. The HBsAg-/anti-HBc+ samples were selected and screened for HBV-DNA by PCR. Those with HBV-DNA were diagnosed as 0131 and PCR-RFLP technique was performed to examine polymorphisms within their Fas gene. Results: 352 (9.5) of 370 0 blood samples were HBsAg-/anti-HBc+. HBV-DNA was detected in 57 (16.1) of 352 HBsAg-/anti-HBc+ samples. Therefore, 57 HBsAg-/anti-HBc+/HBV-DNA+ patients were diagnosed as OBI. Patient and control groups had no significant differences in terms of the studied polymorphisms. Conclusions: The functional polymorphisms in the promoter region of Fas gene are not associated with OBI. Therefore, it may be concluded that polymorphisms at the -670 position of the Fas gene do not have any critical effects on the immune response against HBV in OBI. (C) 2011 Kowsar M.P.Co. All rights reserved.

Item Type: Article
Keywords: Hepatitis B infection Fas Polymorphism HBsAg HBV DNA promoter region c patients ligand expression carcinoma apoptosis system hbv Gastroenterology & Hepatology
Page Range: pp. 23-26
Journal or Publication Title: Hepatitis Monthly
Journal Index: ISI
Volume: 11
Number: 1
ISSN: 1735-143X
Depositing User: مهندس مهدی شریفی

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