Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Serum Levels of IL-10 and IL-17A in Occult HBV-Infected South-East Iranian Patients

(2010) Serum Levels of IL-10 and IL-17A in Occult HBV-Infected South-East Iranian Patients. Hepatitis Monthly. pp. 31-35. ISSN 1735-143X

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Background and Aims: Occult hepatitis B infected (OBI) patients can not completely eradicate hepatitis B virus-DNA (HBV-DNA) from their liver and peripheral blood. The main aim of this study was to investigate the Interleukin (IL)-10 and IL-17A serum levels in patients suffering from OBI. Methods: In this observational study, plasma samples of 3700 blood donors were tested for hepatitis B surface antigen (HBsAg) and antibodies to the hepatitis B core antigen (anti-HBc), using enzyme-linked immunosorbent assay (ELISA). The HBsAg-/anti-HBc+ samples were selected and screened for HBV-DNA, using the polymerase chain reaction (PCR). Hill positive samples were assigned as OBI cases and IL-10 and IL-17 serum levels were detected using ELISA. Results: The results demonstrated that, 352 (9.5) out of 3700 blood samples were HBsAg-/anti-HBc+ and HBV-DNA was detected in 57/352 (16.1) of the HBsAg-/anti-HBc+ samples. Our results showed that the IL-10 and IL-17A serum levels increased significantly in the OBI cases in comparison to the controls (P < 0.001). Conclusions: According to the results of this study the higher level of IL-10 production may suppress the functioning of the immune system against HBV in OBI patients. The elevated IL-17A serum level also indicates a long period of infection in the patients observed.

Item Type: Article
Keywords: Occult Hepatitis B Infection Interleukin-10 Interleukin-17 HBV-DNA hepatitis-b-virus liver-disease cells Gastroenterology & Hepatology
Page Range: pp. 31-35
Journal or Publication Title: Hepatitis Monthly
Journal Index: ISI
Volume: 10
Number: 1
ISSN: 1735-143X
Depositing User: مهندس مهدی شریفی

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