Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Cytokine patterns after therapy with Avonex (R), Rebif (R), Betaferon (R) and CinnoVex (TM) in relapsing-remitting multiple sclerosis in Iranian patients

(2010) Cytokine patterns after therapy with Avonex (R), Rebif (R), Betaferon (R) and CinnoVex (TM) in relapsing-remitting multiple sclerosis in Iranian patients. Biomarkers in Medicine. pp. 755-759. ISSN 1752-0363

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Abstract

Aim: Several lines of evidence exist which suggest that changes in the expression of circulating cytokines are linked to the development or reoccurrence of multiple sclerosis (MS). This study aimed to evaluate the serum levels of relevant cytokines after therapy with IFN-beta formulations in MS patients. Materials & methods: In this study, blood samples were collected from 70 MS patients undergoing four different types of IFN-beta formulation treatment and 100 healthy controls. After 24 months of treatment, the serum levels of IL-17A, IL-12, IFN-gamma and IL-10 in patients and healthy controls were analyzed by ELISA. Results: Our results demonstrated that serum levels of IL-17A were significantly higher in patients treated with CinnoVex (TM) and Avonex (R) when compared with healthy controls. Serum levels of IL-10 were significantly decreased after therapy with CinnoVex, whereas serum levels of IFN-beta were elevated. No difference in serum levels of IL-12 were detected between patients and controls. Conclusion: Results of our study suggest that CinnoVex and Avonex modulate the immune system less than Rebif (R) and Betaferon (R) in MS patients, and an elevated dose of CinnoVex and Avonex may be required for better regulation of the immune system in MS patients.

Item Type: Article
Keywords: Avonex (R) Betaferon (R) CinnoVex (TM) cytokine multiple sclerosis Rebif (R) interferon-beta interleukin-12 ifn-beta-1a ms Research & Experimental Medicine
Page Range: pp. 755-759
Journal or Publication Title: Biomarkers in Medicine
Journal Index: ISI
Volume: 4
Number: 5
Identification Number: https://doi.org/10.2217/bmm.10.81
ISSN: 1752-0363
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4850

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