Repository of Research and Investigative Information

Repository of Research and Investigative Information

Rafsanjan University of Medical Sciences

Impact of Opium on the Serum Levels of TGF-beta in Diabetic, Addicted and Addicted-Diabetic Rats

(2010) Impact of Opium on the Serum Levels of TGF-beta in Diabetic, Addicted and Addicted-Diabetic Rats. Iranian Journal of Immunology. pp. 186-192. ISSN 1735-1383

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Abstract

Background: Several cells of immune system such as regulatory T cells and macrophages secrete transforming growth factor-beta (TGF-beta) in response to different stimuli. This cytokine has inhibitory effect on immune system and diminished production of this cytokine is associated with autoimmune disorders. Objective: The aim of this study was to evaluate the influence of opium addiction on serum level of TGF-beta in male and female diabetic and non-diabetic Wistar rats. Methods: This experimental study was performed on normal, opium addicted, diabetic and addicted-diabetic male and female rats. Serum level of TGF-beta was measured by ELISA. Results: The results of our study indicated that the mean serum level of TGF-beta in female addicted rats was significantly increased compared to control group (p < 0.004). Conversely, in male addicted rats the mean serum level of TGF-beta was lower compared with control (p < 0.065). Conclusion: Our results suggest that opium and its derivatives have differential inductive effects on the cytokine expression in male and female rats.

Item Type: Article
Keywords: Addiction Diabetes Opium TGF-beta Immunology
Page Range: pp. 186-192
Journal or Publication Title: Iranian Journal of Immunology
Journal Index: ISI
Volume: 7
Number: 3
ISSN: 1735-1383
Depositing User: مهندس مهدی شریفی
URI: http://eprints.rums.ac.ir/id/eprint/4854

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